N-acetylaspartate normalization in bipolar depression after lamotrigine treatment
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چکیده
منابع مشابه
N-acetylaspartate normalization in bipolar depression after lamotrigine treatment.
OBJECTIVES The aim of the present study was to examine N-acetylaspartate (NAA), a general marker of neuronal viability, and total NAA (tNAA), the combined signal of NAA and N-acetylaspartylglutamate, in bipolar depression before and after lamotrigine treatment. Given that NAA is synthesized through direct acetylation of aspartate by acetyl-coenzyme A-l-aspartate-N-acetyltransferase, we hypothes...
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متن کاملLamotrigine use in geriatric patients with bipolar depression.
OBJECTIVE To study the effectiveness of adding lamotrigine to the treatment of inpatient geriatric patients with bipolar disorder (BD) who were in the depressed phase and had been on lithium and valproate for at least 3 months. METHOD Lamotrigine was started at 25 mg given at bedtime, with weekly incremental increases of 12.5 mg daily until a total dosage of either 75 mg or 100 mg was obtaine...
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Two cases of patients experienced subsyndromal depression after manic or mixed hypomanic and depressive episodes due to bipolar I (case 1) and II (case 2) disorders prior to the use of lamotrigine. Case 1 showed episodes of mood switching induced by antidepressants and seasonal mood instability. Case 2 showed hippocampal atrophy and a persistent dull headache that preceded the use of lamotrigin...
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ژورنال
عنوان ژورنال: Bipolar Disorders
سال: 2014
ISSN: 1398-5647
DOI: 10.1111/bdi.12285